The 2006 FIFA World Cup CONMEBOL–OFC qualification play-off was a two-legged home-and-away tie between the winners of the Oceania qualifying tournament, Australia, and the fifth-placed team from the South American qualifying tournament, Uruguay. It still remains as the only match where a country has qualified for the FIFA World Cup Finals on a penalty shoot-out.

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After winning the series, Australia qualified for the 2006 FIFA World Cup held in Germany.